Birmingham City Council has approved plans for its HS2 Curzon Street station.
Councillors recommended planning applications for a new railway station during an online meeting on April 23.
The plans include a new northern terminal connecting Birmingham to London Euston through Birmingham interchange and Old Oak Common.
The approval follows on from the DfT giving the "notice to proceed" to contractors working on building and developing HS2.
HS2 will provide high-speed train routes linking London to cities including Birmingham, Manchester and Leeds.
The construction and design work is worth a total of £12 billion in contracts through joint ventures and contractors.
Once operational, HS2 will serve over 25 stations connecting around 30 million people.
Mark Thurston, HS2 chief executive, said: "HS2 has been over 10 years in development and design.
"While the country’s focus is rightly on defeating COVID-19, the issuing of Notice to Proceed ensures that our contractors and their supply chains have the confidence that they can commit to building HS2, generating thousands of skilled jobs across the country as we recover from the pandemic.”